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Two ginsenoside derivatives (1, 2) along with 2 known ginsenosides (3, 4) were isolated from the acid hydrolysis products of pseudoginsenoside-F 11 . Their structures were elucidated on the basis of spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS. Among them, (12 R, 20 S, 24 S)-20, 24; 12, 24-diepoxy-dammarane-3β, 6α-diol (1) and (20 R, 24 R)-dammar-20, 24-epoxy-3β, 6α, 12β, 25-tetraol (2) were identified as new triterpenoid saponins. They were subjected to assay for cytotoxic activities against six human tumor cells lines.

Two New Triterpenoid Saponins from the Structural Modification of Pseudoginsenoside-F11 and their Cytotoxic Activities

Two New Triterpenoid Saponins from the Structural Modification of Pseudoginsenoside-F₁₁ and their Cytotoxic Activities