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An antibacterial assay-guided isolation of the crude ethyl acetate extract from Ficus foveolata stems afforded four compounds, including a tetrahydronaphthalene lignanamide, foveolatamide (1), together with two known lignanamides, flavifloramide B (2) and N-trans-grossamide (3), and a known phenolic amide, N-trans-feruloyltyramine (4). The structures of these compounds were established on the basis of NMR spectroscopic and MS techniques. Among the isolated compounds, only 1 showed satisfactory antibacterial activities against Streptococcus pyogenes, with an MIC and MBC value of 45 μM. This is the first report of these four compounds from the stems of F. foveolata.

A New Antibacterial Tetrahydronaphthalene Lignanamide, Foveolatamide, from the Stems of Ficus Foveolata