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Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25 S)-spirost-5-en-3-ol 3- O-α-L-rhamnopyranosyl-(1→2)- O-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC 50  values of 12.45 and 59.03 μM, respectively.

Steroidal Glucosides from the Rhizomes of Tacca Chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells