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Two new prenylhydroquinone-derived compounds, lentinospirol (1) and 1-(2,5-dihydroxyphenyl)-4-hydroxy-3-methyl-1-butanone (2), were isolated from cultures of the basidiomycete Lentinus similis BCC 52578, together with the known compounds panepoxydone (3), panepoxydione (4), isopanepoxydone (5), 2,2-dimethyl-6-hydroxy-2 H-chromene (6), and (3 R,4 S)-3,4-dihydroxy-2,2-dimethyl-6-methoxychroman (7). Compounds 3 and 4 exhibited cytotoxicity against all cell-lines tested, while the other compounds were inactive.

Prenylhydroquinone-Derived Secondary Metabolites from Cultures of the Basidiomycete Lentinus Similis BCC 52578