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The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC 50 : 26.1±1.9 μM) showed the strongest cytotoxic properties similar to those of curcumin (CC 50 : 8.1±1.7 μM). Further studies also revealed that the cytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein

Cytotoxic Active Constituents of Essential Oils of Curcuma longa and Curcuma zanthorrhiza