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The stem bark extracts of Bauhinia rufescens Lam. (Fabaceae) yielded 6-methoxy-7-methyl-8-hydroxydibenz[ b,f]oxepin, α-amyrin acetate, β-sitosterol 3- O-β-D-xylopyranoside, 4-(2′-Hydroxyphenethyl)-5-methoxy-2-methylphenol, menisdaurin and sequoyitol. Their structures were determined using spectroscopic methods and comparisons with the literature data. For the antimicrobial assay Gram-positive and Gram-negative bacterial and fungal strains were tested, while the tyrosinase inhibition assay utilized L-DOPA as a substrate for the tyrosinase enzyme. 6-Methoxy-7-methyl-8-hydroxydibenz[ b,f]oxepin, α-amyrin acetate, β-sitosterol 3- O-β-D-xylopyranoside, menisdaurin and sequoyitol showed weak to moderate activities with minimum inhibition concentration (MIC) values in the range of 112.5–900 μg/mL against all bacterial strains, while the MIC values for the fungal strains were in the range of 28.1–450 μg/mL. In the tyrosinase inhibition assay, α-amyrin acetate was found to be moderately active against tyrosinase with an inhibition of 62% at 0.1 mg/mL. This activity was lower than that of the positive control, kojic acid (85%).

Potent Microbial and Tyrosinase Inhibitors from Stem Bark of Bauhinia Rufescens (Fabaceae)