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In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A 2 -2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of mouse Ehrlich carcinoma. They prevent in this way an efflux of fluorescent probe Calcein from the cells. Since the blocking of P-glycoprotein activity results in decrease of multidrug resistance, these glycosides and their complexes with cholesterol may be considered as potential inhibitors of multidrug resistance of tumor cells.

Inhibition of Tumor Cells Multidrug Resistance by Cucumarioside A2-2, Frondoside A and their Complexes with Cholesterol

Inhibition of Tumor Cells Multidrug Resistance by Cucumarioside A₂-2, Frondoside A and their Complexes with Cholesterol