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Biotransformation of deoxyandrographolide (1) by Alternaria alternata AS 3.4578 gave five derivatives identified by spectral methods including 2D NMR as the known dehydroandrographolide (2) and 9β-hydroxy-dehydroandrographolide (3) and the new compounds 9β-hydroxy-deoxyandrographolide (4), 3α,17,19-trihydroxy-8,13-ent-labdadien-15,16-olide (5) and 3-oxo-9β-hydroxy-deoxyandrographolide (6).

Microbial Transformation of Deoxyandrographolide by Alternaria Alternata AS 3.4578