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The purpose of the present study was to evaluate the pharmacokinetic interaction of vitexin rhamnoside (vitexin 2″-α-L-rhamnopyranosyl) and vitexin glucoside (vitexin 2″-β-D-glucopyranosyl) in rats by using a high performance liquid chromatography coupled with tandem mass spectrometry quantitative detection method (LC-MS/MS). The method was validated at the concentration range of 5 - 5000 ng/mL for both vitexin rhamnoside and vitexin glucoside with the regression equations Y = 0.00181X - 0.000955 ( r &gt; 0.998) and Y = 0.000788X - 0.000373 ( r &gt; 0.997), respectively. The methodological studies (including linearity, intra-assay / inter-assay accuracy and precision) of these two components were investigated. The pharmacokinetic parameters of these two components were compared, which demonstrated their pharmacokinetic variance, especially when they were administrated simultaneously.

Simultaneous Determination of Vitexin Rhamnoside and Vitexin Glucoside in Rats by Liquid Chromatography Coupled with Mass Spectrometry