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Cleome viscosa (Capparidaceae) is used in fever, inflammation and liver diseases. Systematic investigation of the seeds of this species has resulted in the isolation of three coumarinolignoids, cleomiscosin A, B and C. The present study was undertaken to determine the immunomodulatory activity of these coumarinolignoids using inbred female Swiss albino mice as an in-vivo study. Experimental animals were divided into six groups, each comprised of six mice. These received oral treatment for a period of 28 days. Body weight variation, and hematological, humoral and cell mediated immune response related parameters were studied in which coumarinolignoids at a dose of 10 mg/kg body weight enhanced the body immune function by significantly increasing the white blood cell count, hemagglutination antibody titer responses, and reducing delayed type hypersensitivity response towards rabbit red blood cells.

An in-vivo Study of the Immunomodulatory Activity of Coumarinolignoids from Cleome viscosa