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Two new sulfated steroids, 3β, 5α, 6β- trihydroxy-24-methylene-cholesta-7-ene-3-sodium sulfate (1) and 3β, 5α, 6β-trihydroxy-23 E-24-methyl-cholesta-7,23-diene-3-sodium sulfate (2) have been isolated from the sponge, Lendenfeldia dendyi. Their structures were determined on the basis of extensive spectroscopic data (IR, HRMS,  1 H and  13 C NMR, HMQC, HMBC, COSY and ROESY). The two metabolites lacked antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium intracellulare, Aspergillus fumigatus, and methicillin-resistant Staphylococcus aureus (MRSa).

Two New Sulfated Sterols from the Marine Sponge Lendenfeldia dendyi