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The stems of Cissus quadrangularis L (Vitaceae) have been consumed for centuries throughout Asia and Africa as a culinary vegetable. The aqueous extract of C. quadrangularis stems and leaves contains flavonoids and stilbenes, which inhibit lipase, amylase and α-glucosidase and, therefore, might be, at least in part, related to the claimed anti-obesity activity of the plant. The enzyme inhibition activity is outlined of a novel flavonoid (3- O-α-L-rhamnopyranosylkaempferol) (2) and stilbene (3-(4-hydroxybenzylidene)-2-(2,5-dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol) (7), four known structurally related flavonoids, and one stilbene isolated from the extract.

Inhibitory Effects of Cissus quadrangularis L. Derived Components on Lipase, Amylase and α-Glucosidase Activity in vitro