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The cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide (2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC 50  values for 1 and 2 were found to be 8.5 and 26.4 μM, respectively.

Two Salonitenolide Derivatives from the Aerial Parts of Centaurea Gigantea Inhibit the Growth of Colorectal Cancer Cells in Vitro