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Many genes are differentially expressed in normal compared to anencephalic human fetal adrenals (HFAs), especially the Fras-1-related extracellular matrix protein (FREM2) gene. FREM2 expression appears to be regulated by adrenocorticotrophic hormone (ACTH).

reproductive sciences

Differential Gene Expression in the Adrenals of Normal and Anencephalic Fetuses and Studies Focused on the Fras-1-Related Extracellular Matrix Protein (FREM2) Gene