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Hemoglobin A1c (HbA1c) is highly correlated with mean blood glucose (MBG) levels and widely used in assessment of diabetes therapy. It has been proposed to report HbA1c in terms of an estimated average glucose (eAG) derived from the population regression of MBG on HbA1c. Pertinent to the clinical utility of eAG would be the degree of agreement between eAG and MBG estimated from multiple sampled glucose measurements over time.

Clinically Significant Disagreement between Mean Blood Glucose and Estimated Average Glucose in Two Populations: Implications for Diabetes Management