Open AccessTIMP-3 as a therapeutic target for cancer
Author(s) -
Su Chun-Wen,
Lin Chiao-Wen,
Yang Wei-En,
Yang Shun-Fa
Publication year - 2019
Publication title -
therapeutic advances in medical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 49
eISSN - 1758-8359
pISSN - 1758-8340
DOI - 10.1177/1758835919864247
Subject(s) - medicine , cancer , biomarker , cancer research , carcinogenesis , epigenetics , matrix metalloproteinase , cancer cell , cancer biomarkers , cancer therapy , extracellular matrix , bioinformatics , biology , microbiology and biotechnology , biochemistry , gene
Tissue inhibitor of metalloproteinase-3 (TIMP-3), a secreted glycoprotein, plays an important role in carcinogenesis. It can bind to many proteinases to suppress their activity and thus protect the extracellular matrix from degradation. TIMP-3 may have many anticancer properties, including apoptosis induction and antiproliferative, antiangiogenic, and antimetastatic activities. This review summarizes the structure, proteinase inhibition ability, genetic and epigenetic regulation, cancer therapy potential, and contribution to cancer development of TIMP-3. Furthermore, in this review we discuss its potential as a biomarker for predicting cancer progression and the current state of drugs that target TIMP-3, either alone or in combination with clinical treatment. In conclusion, TIMP-3 can be a biomarker of cancer and a potential target for cancer therapy. This review article can serve as a basis to understand how to modulate TIMP-3 levels as a drug target of cancers.
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