Open AccessInvestigating the therapeutic role and molecular biology of curcumin as a treatment for glioblastoma
Author(s) -
Gregor A. Rodriguez,
Ashish H. Shah,
Zachary C. Gersey,
Sumedh S. Shah,
Amadé Bregy,
Ricardo J. Komotar,
Regina M. Graham
Publication year - 2016
Publication title -
therapeutic advances in medical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 49
eISSN - 1758-8359
pISSN - 1758-8340
DOI - 10.1177/1758834016643518
Subject(s) - curcumin , glioblastoma , medicine , pharmacology , apoptosis , oncology , cancer research , biology , biochemistry
Despite the aggressive standard of care for patients with glioblastoma multiforme, survival rates typically do not exceed 2 years. Therefore, current research is focusing on discovering new therapeutics or rediscovering older medications that may increase the overall survival of patients with glioblastoma. Curcumin, a component of the Indian natural spice, turmeric, also known for its antioxidant and anti-inflammatory properties, has been found to be an effective inhibitor of proliferation and inducer of apoptosis in many cancers. The goal of this study was to investigate the expanded utility of curcumin as an antiglioma agent.
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