English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Phytomedicine is becoming more acceptable as an alternative medicinal approach in the modern era.    Objectives: The current study examined the antioxidant capacity and in vitro response of phytochemical constituents of  Withania somnifera (Ashwagandha) on standard parameters of healthy volunteer semen.    Methods: The phytochemicals and their pharmacological response in a hydroethanolic (30:70 v/v) extract of  W.  somnifera roots were determined using standard protocols.    Results: The constituents included flavonoids, phenolic acids, alkaloids, and terpenoids were reported. High-performance liquid chromatography and Fourier-transform infrared spectroscopy determined a diverse array of biologically active chemical constituents in the extract. The extract of  W. somnifera exhibits substantial antioxidant properties, including total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl inhibition, H 2 O 2  scavenging, and Fe 3+  reducing potential ( P &lt; .05). The analysis of essential natural minerals explored adequate levels determined using atomic absorption spectrophotometer. Cytotoxic studies revealed significant thrombolytic, RBC membrane stabilization, and DNA damage protection activity ( P &lt; .05) while remaining non-mutagenic against  Salmonella typhi TA98 and TA100. The best protective response of  W. somnifera extract on human semen parameters (n = 30), such as total motility, progressive motility, and viability, demonstrated a significant ( P &lt; .05) improvement, particularly at the dose of 25 μg/mL and 50 μg/mL.    Conclusion: The study concludes that  W. somnifera possesses favorable in vitro characteristics that could aid in the preservation of sperm during intrauterine insemination and in vitro fertilization.

Withania somniferaChemical Constituents’ In Vitro Antioxidant Potential and Their Response on Spermatozoa Parameters