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A novel cellular homing/chemokine delivery system was developed, in which electrospun polydioxanone (PDO) scaffolds infused with Monocyte Chemotactic Protein-1 (MCP-1) were fabricated and examined for their potential to influence macrophage infiltration/adherence and for their potential to provide extended chemokine release. Over the course of 120 hours, MCP-1 released into supernatant peaked at 24 hours and was detectable by enzyme-linked immunosorbent assay (ELISA) when added to PDO solutions prior to electrospinning at 3000 ng/ml. PDO/MCP-1 hybrids were characterized for biological activity using a test tube ELISA procedure assessing macrophage adherence/infiltration of scaffolds. Results demonstrated an increasing dose-responsive trend with increasing MCP-1 concentration. These initial investigations suggest such hybrid materials have significant potential for use in and improvement of in situ tissue regeneration applications by acting as cellular homing devices.

Feasibility of Electrospun Polydioxanone — Monocyte Chemotactic Protein-1 (MCP-1) Hybrid Scaffolds as Potential Cellular Homing Devices