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In animal stroke models, peri-infarct cortical stimulation (CS) combined with rehabilitative reach training (RT) enhances motor functional outcome and cortical reorganization, compared with RT alone. It was unknown whether the effects of CS + RT (a) persist long after treatment, (b) can be enhanced by forcing greater use of the paretic limb, and (C) vary with treatment onset time.

Enduring Poststroke Motor Functional Improvements by a Well–Timed Combination of Motor Rehabilitative Training and Cortical Stimulation in Rats