English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Functionalized single-walled carbon nanotubes are currently being explored as novel delivery vehicles for proteins and therapeutic agents to treat various diseases. In order to maximize treatment efficacy, a strong binding between single-walled carbon nanotubes and their functionalized molecules is necessary. Glycated chitosan, a polymer with potent immunostimulatory properties for cancer treatment, has been used as a surfactant of single-walled carbon nanotubes to form an immunologically modified nanosystem for biomedical applications. In this study, we investigated the binding characteristics of single-walled carbon nanotube and glycated chitosan using molecular dynamics simulations. The mean square displacement, radius of gyration, interaction energy, and radial distribution function of the single-walled carbon nanotube-glycated chitosan system were analyzed. The results from the simulations demonstrated that glycated chitosan was bound to single-walled carbon nanotubes by a strong, noncovalent interaction. The stability of glycated chitosan on the single-walled carbon nanotubes surface was enhanced by the length of glycated chitosan, and the binding energy of the 2 molecules was closely related to the diameter and chirality of single-walled carbon nanotubes, with the most stable single-walled carbon nanotube-glycated chitosan system being formed by the combination of long polymer, large single-walled carbon nanotube, and armchair single-walled carbon nanotube. The understanding of the interactions between single-walled carbon nanotube and glycated chitosan and the structure of single-walled carbon nanotube-glycated chitosan allows the modifications of the novel nanosystem for disease diagnostics and therapeutics.

An Immunologically Modified Nanosystem Based on Noncovalent Binding Between Single-Walled Carbon Nanotubes and Glycated Chitosan