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Blood pressure is lower in females than males. Angiotensin II type-2 receptor (AT 2 R) induces vasodilation. This study determined whether sex differences in vascular AT 2 R expression occur and if androgens exert control on AT 2 R expression in the vasculature.

Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta