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Rudolf A de Boer,1 Michel Azizi,2 AH Jan Danser,3 Genevieve Nguyen,4 Jurg Nussberger,5 Luis M Ruilope,6 Roland E Schmieder7 and Massimo Volpe8 1University Medical Center Groningen, Department of Cardiology, University of Groningen, the Netherlands 2Universite Paris-Descartes, Assistance Publique des Hopitaux de Paris, Departement d’Hypertension Arterielle, France 3Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, the Netherlands 4Centre for Interdisciplinary Research in Biology (CIRB), France 5Division of Angiology and Hypertension, Centre Hospitalier Universitaire Vaudois, Switzerland 6Hypertension Unit, Hospital 12 de Octubre and Department of Public Health and Preventive Medicine, Universidad Autonoma, Spain 7University Hospital Erlangen, Nephrology and Hypertension, Germany 8Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome “Sapienza”and IRCCS Neuromed, Italy Email: r.a.de.boer@umcg.nl RAAS Working Group Update

Dual RAAS suppression: recent developments and implications in light of the ALTITUDE study