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We assessed the prevalence and clinical impact of insertions within the HIV-1 p6 Gag  proline-rich (PTAP) region on initial antiretroviral therapy response in 461 HIV-infected, drug-naive individuals initiating therapy in British Columbia, Canada between June 1996 and August 1998. HIV p6 Gag  insertions were detected by nested RT-PCR of extracted patient plasma followed by direct DNA sequencing. Insertions were observed in 70 of 423 successfully genotyped samples (16.5%). HIV p6 Gag  insertions were significantly associated with a lower baseline CD4 cell count (P 0.1). The data suggest that HIV p6 Gag  insertions are not exclusively related to drug resistance and may not influence response to antiretroviral therapy, but may be linked to sequence variations in the HIV envelope.

antiviral therapy

Prevalence and clinical implications of insertions in the HIV-1 p6<sup>Gag</sup> N-terminal region in drug-naive individuals initiating antiretroviral therapy

Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy

Prevalence and clinical implications of insertions in the HIV-1 p6^Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy