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A human brain has separate left and right cerebral cortices, each of which must be continuously structurally maintained during adulthood. There is no understanding of how ongoing structural maintenances of separate parts of a mature individual brain, including the 2 cortices, are related. To explore this issue, this study used an unconventional N-of-1 magnetic resonance imaging time-series paradigm to identify relationships between maintenances of structural thicknesses of the 2 cortices in an adult human brain over week intervals for 6 months. The results suggest that maintenances of left and right cortical thicknesses were symmetrically related in some, but asymmetrically related in other, respects. For matched times, thickness magnitudes and variations on the 2 sides were positively correlated and appeared to reflect maintenance symmetry. Maintenance relationships also extended from earlier to later times with temporal continuity and apparent "if-then" contingencies which were reflected in symmetry and asymmetry dynamics spanning 1- to 2-week periods. The findings suggest concepts of individual brain cortical maintenance symmetry, asymmetry, and temporal continuity dynamics that have not been previously recognized. They have implications for defining cortical maintenance traits or states and for development of N-of-1 precision medicine paradigms that can contribute to understanding individual brain health.

Relationships in Ongoing Structural Maintenances of the Two Cerebral Cortices of an Individual Brain