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Herein (the first part of my work), I debunk the long-standing hypothesesthat explain mitochondrial oxidative phosphorylation. Simple calculations pointout that mitochondria are highly proton-deficient microcosms and therefore,elaborate proton pump machinery are not tenable. Further, other elements likethe elaborate electron transport chain, chemiosmosis, rotary ATP synthesis,etc. are also critically evaluated to point out that such complicated systemsare non-viable. The communication necessitates a new explanatory paradigm forcellular respiration. In the second part of my work, I have put forward aviable alternative explanatory paradigm for mitochondrial oxidativephosphorylation.

Mitochondrial oxidative phosphorylation: Debunking the concepts of electron transport chain, proton pumps, chemiosmosis and rotary ATP synthesis