English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Due to the rarity of primary bone tumors, few physicians accumulate enough experience in the diagnosis and treatment of these neoplasias. Clinical management is best achieved through a multidisciplinary approach in which surgeon, radiologist, medical oncologist, and pathologist combine their expertise to establish both an accurate diagnosis and a rational treatment plan. The diagnostic algorithm of a primary tumor of the bone is, and always has been, a collaborative effort in which clinical, radiologic, and pathologic features have to be considered. In the majority of cases, the pathologist can rely exclusively on histopathologic examination to provide an accurate diagnosis. In some cases, however, a variety of ancillary studies have to be employed to distinguish entities that share morphologic characteristics. Currently, immunohistochemistry has limited application in the differential diagnosis of primary bone tumors, but occasionally, characterization of the antigenic profile is the only way to properly classify a given neoplasia. Furthermore, immunohistochemical analysis is helping us to establish the histogenetic origin of many entities and to understand their pathogenesis.

The Role of Immunohistochemistry in the Diagnosis of Primary Tumors of the Bone