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Syringomyelia is a common clinical problem in the Cavalier King Charles Spaniel dog population. The underlying pathophysiology of the development and progression of syringes is currently unknown. The primary aim of the current study was to determine whether development of syringomyelia is accompanied by alterations in cerebrospinal fluid composition. Patient records of Cavalier King Charles Spaniels with Chiari-like malformations, with or without concurrent syringomyelia, that had magnetic resonance imaging and cerebrospinal fluid analysis between December 2004 and December 2009, were retrospectively reviewed. Total nucleated cell count per microliter, with differential count, red blood cell count per microliter, and protein concentration (g/l), were reviewed. Data were analyzed with the Mann–Whitney U-test. Spearman rank test was used to test association between cerebrospinal fluid composition and syrinx size, and the Fisher exact test was used to compare the presence of macrophages, reactive lymphocytes, and myelin. A P value of ≤0.05 was considered significant for statistical tests. Dogs with syringomyelia had a higher total nucleated cell count (syringomyelia: 4/μl [range, 0–15/μl] vs. without syringomyelia: 2/μl [0–8/μl]; P = 0.0047), higher protein concentration (syringomyelia: 0.26 g/l [0.07–0.42 g/l] vs. without syringomyelia: 0.2 g/l [0.12–0.39 g/l]; P = 0.039), and an increased neutrophil percentage (syringomyelia: 0% [0–37%] vs. without syringomyelia: 0% [0–21%]; P = 0.0203) than those with the Chiari-like malformation alone. There was a positive correlation between total nucleated cell count and syrinx size ( r = 0.51; P = 0.0068). Development of syringomyelia is accompanied by alterations in cerebrospinal fluid composition. The pathogenesis of syringomyelia has not been fully elucidated; therefore, the exact origin of cerebrospinal fluid changes remains unclear.

journal of veterinary diagnostic investigation

Evaluation of Cerebrospinal Fluid in Cavalier King Charles Spaniel Dogs Diagnosed with Chiari-Like Malformation with or without Concurrent Syringomyelia