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Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn “virgin” immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p&lt;0.001), with a low percentage of cytokine producing cells, confirming the immaturity of the newborn's immune system. CBTL percentage of IL-2 producing cells was higher for helper than cytotoxic subset (p&lt;0.001). We observed a greater percentage of IFN-γ (p=0.001), IL-4 (p=0.003) and IL-10 (p&lt;0.001) producing cells by cytotoxic than helper T lymphocytes. CoTL demonstrated to protect the newborn through the mother's previous immune experience and to supply active cytokines, which can help the postnatal development of both T type 1/T type 2 response.

Human Colostrum T Lymphocytes and Their Effector Cytokines Actively Aid the Development of the Newborn Immune System