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The new neuromuscular blocker, Org NC 45 was applied to the toad sartorius nerve-muscle preparation. Measurement of the variance ratio of end-plate potentials recorded by micro-electrodes demonstrated that in concentrations greater than that required to block myoneural transmission, Org NC 45 reduced the quantal release of acetylcholine.

Org NC 45 Reduces Quantal Release of Acetylcholine (a Preliminary Communication)