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In infants and piglets subjected to periods of circulatory arrest at 20°C there was close correlation between duration of arrest and delay in return of electroencephalographic activity. Post mortem studies demonstrated histological evidence of brain damage in patients after circulatory arrest at 20°C. Similar histological changes were demonstrated in piglets, including some who had complete E.E.G. and clinical recovery from circulatory arrest.

The Influence of Duration of Circulatory Arrest at 20°C on Cerebral Changes