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Objective   To explore the relationship between the omentin-1 gene rs2274907 A&gt;T polymorphism and colorectal cancer (CRC) in the Chinese Han population.Methods   rs2274907 A&gt;T was assessed by PCR–restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m 2 .Results   No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A&gt;T. Compared with individuals with BMI  T polymorphism does not seem to play a critical role in the development of CRC in the Chinese Han population, but an interaction between the rs2274907 A allele and BMI may increase the CRC risk. The rs2274907 AA genotype is a potential biomarker for CRC stage progression.

Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study