Open AccessImmune reconstitution inflammatory syndrome associated with Pneumocystis pneumonia in a patient with AIDS
Author(s) -
Ying Wen,
Meng-chan Wang,
Ying Zhou,
Xuyong Lin,
Gang Hou,
Yan Yin
Publication year - 2020
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060520946544
Subject(s) - immune reconstitution inflammatory syndrome , medicine , pneumocystis jirovecii , pneumocystis pneumonia , pneumocystis carinii , pneumonia , bronchoscopy , lung , human immunodeficiency virus (hiv) , immunology , antiretroviral therapy , viral load
Immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment for human immunodeficiency virus (HIV) infection has a wide variety of causes. Delayed diagnosis and treatment of IRIS is fatal. We report a case of a 21-year-old man with HIV infection and Pneumocystis jirovecii pneumonia. The patient presented with fever and dyspnea with deterioration of pulmonary infiltrations 5 days after starting antiretroviral treatment. We reached the diagnosis of IRIS based on radial endobronchial ultrasound (EBUS)-guided lung biopsy. In conclusion, radial EBUS-guided lung biopsy via bronchoscopy is a valuable and minimally invasive technique for the rapid diagnosis of IRIS-associated Pneumocystis jirovecii pneumonia.
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