Open AccessAnalysis of pancreatic fistula risk in patients with laparoscopic pancreatoduodenectomy: what matters
Author(s) -
Kate g,
Yue Zhang,
Shengyong Liu,
Yue Yang,
Donglin Sun,
Xuemin Chen
Publication year - 2020
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060520943422
Subject(s) - medicine , pancreatic fistula , body mass index , univariate analysis , pancreas , incidence (geometry) , pancreaticoduodenectomy , surgery , retrospective cohort study , logistic regression , risk factor , fistula , general surgery , multivariate analysis , physics , optics
Objective To analyse potential risk factors for postoperative pancreatic fistula (POPF).Methods A retrospective study on risk factors for POPF was conducted in patients undergoing laparoscopic pancreatoduodenectomy. Basic characteristics, and preoperative, intraoperative and postoperative patient data were collected and analysed.Results A total of 268 patients were enrolled in this study, including 54 patients with POPF following surgery (POPF incidence, 20.15%). Univariate analysis indicated that patient’s age, body mass index (BMI), preoperative bilirubin level, pancreas texture, and drainage fluid amylase level on day 1 following surgery were associated with POPF. Multiple logistic regression analysis indicated that preoperative bilirubin level ≥170 µmol/l, soft pancreas texture, BMI ≥25, and age ≥65 years were independent risk factors associated with POPF.Conclusions For patients with preoperative bilirubin level ≥170 µmol/l, soft pancreas texture, BMI ≥25 and age ≥65 years, clinically relevant measures should be taken as early as possible for the prophylaxis of POPF.