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After inoculation of herpes simplex virus (HSV) on the snout of the mouse, spread to the eye occurs via neural pathways. The keratitis which ensued was clinically atypical for a pure herpetic keratitis, leading to a search for other causative agents. Preliminary data suggests that bacteriological superinfection of the viral keratitis occurs frequently, producing a unique experimental model.

journal of the royal society of medicine

Preliminary Data Suggest a Role for Bacterial Superinfection of a Viral Keratitis after Zosteriform Spread of Herpes Simplex virus to the Eye of the Mouse