Open AccessProtective Role of Faecal pH in Experimental Colon Carcinogenesis
Author(s) -
S. Samelson,
Richard L. Nelson,
Lloyd M. Nyhus
Publication year - 1985
Publication title -
journal of the royal society of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.38
H-Index - 81
eISSN - 1758-1095
pISSN - 0141-0768
DOI - 10.1177/014107688507800311
Subject(s) - colorectal cancer , gastroenterology , dimethylhydrazine , lactulose , 1,2 dimethylhydrazine , medicine , feces , carcinogenesis , chemistry , biology , cancer , microbiology and biotechnology
There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
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