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At the end of 2003, the Journal of the Royal Society of Medicine published an article announcing the creation of the James Lind Initiative (JLI).1 The article began by recalling the way that James Lind, an 18th century Scottish naval surgeon, had confronted uncertainty about how to treat scurvy by doing a controlled trial. This had shown that oranges and lemons were a very effective cure for an often lethal disease.2,3 The 2003 article went on to suggest that therapeutic uncertainties today should also be confronted in research as an integral element of responsible healthcare, and that the JLI was being established to promote this principle. The current article describes the origins of the JLI and its work over the past 10 years.

Tackling treatment uncertainties together: the evolution of the James Lind Initiative, 2003–2013