Diaphyseal Aclasis

The slice fixed in formaldehyde shows branching and anastomosing trabecule of glandular tissue in abundant adipose tissue. The trabecule are in general narrow. They are frequently formed by only two rows of cells; occasionally the cells are then columnar and surround an empty lumen. Most of the cells are chief cells. They are almost all vacuolated, but completely water-clear cells are relatively rare. One small group of trabecule is occupied almost entirely by pale oxyphil cells; other oxyphil cells are scattered throughout. There is in this slice no evidence of hyperplasia. A similar structure is seen in the piece subjected to Da Fano's method. In the portion treated by Gatenby's method, however, there is very much less adipose tissue, and the gland is composed of closely packed acini. Further, there is a rounded nodule, 2 mm. in diameter, in wbich septa separating acini are sparse. This nodule contains three cystic spaces containing a thin coagulum and red corpuscles. There is another, smaller, nodule in which the cells are usually large and columnar, and lie upon vascular trabecule to form a net enclosing wide spaces; the spaces contain a few shreds of coagulum. Both these nodules contrast with the rest of the glandular tissue in that the cells do not contain lipoid granules. There is, therefore, in these two nodules evidence of focal hyperplasia. The stain for the Go]gi apparatus was not successful.