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Pathophysiology 1. Pathology of disease o Affected osteoclasts increase in both size and number causing increased rate of bone resorption o In response, osteoblasts form bone in a more rapid and less organized manner, resulting in a mosaic pattern 2. Incidence/prevalence o 1-3% of adults >40 yo o Incidence increases with age 3. Risk factors o Higher prevalence in western Europe (UK, Germany and France) and populations that have immigrated to Australia, North and South America, New Zealand, and South Africa 4. Morbidity/mortality o 70% asymptomatic (most cases discovered incidentally) o Fractures are most common o Deafness o Tumors o Bone deformities

Paget's Disease — Osteitis Deformans