Open AccessThe Presence of v-abl-transformed V3 Mast Cells in the Lungs Augments Pulmonary Vascular Permeability to Acid Aspiration
Author(s) -
Chandrika Mukundan,
Michael F. Gurish,
K. Frank Austen,
Herbert B. Hechtman,
Daniel S. Friend
Publication year - 2001
Publication title -
journal of histochemistry and cytochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 124
eISSN - 1551-5044
pISSN - 0022-1554
DOI - 10.1177/002215540104900614
Subject(s) - lung , mast cell , vascular permeability , adoptive cell transfer , pathology , chemistry , mast (botany) , permeability (electromagnetism) , microbiology and biotechnology , medicine , immunology , biology , membrane , biochemistry , immune system , t cell
Acid aspiration causes pulmonary vascular permeability and PMN sequestration. By increasing pulmonary mast cells through adoptive transfer of v-abl-transformed mast cells (V3MCs) into BALB/c mice, we now show that the greater mast cell number in the lung is associated with increased pulmonary injury.
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