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Depression may be a precursor to substance use disorder in some youngsters, and substance abuse might complicate the subsequent course of depression. This study examined whether hypothalamic-pituitary-adrenal (HPA) activity and stressful life experiences are related to the development of substance use disorder in depressed and nondepressed adolescents, and whether substance use disorder predicts a worsening course of depression.

Mechanisms Underlying the Comorbidity Between Depressive and Addictive Disorders in Adolescents: Interactions Between Stress and HPA Activity