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No Evidence for an Effect of COMT Val158Met Genotype on Executive Function in Patients With 22q11 Deletion Syndrome
Author(s) -
Bronwyn Glaser,
Martin Debbané,
Christine Hinard,
Michael A. Morris,
Sophie Dahoun,
Stylianos E. Antonarakis,
Stéphan Eliez
Publication year - 2006
Publication title -
american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.163.3.537
Subject(s) - deletion syndrome , genotype , function (biology) , medicine , psychology , genetics , biology , phenotype , gene
Previous studies linking the catechol O-methyltransferase (COMT) functional polymorphism to the specific phenotype in 22q11.2 deletion syndrome (22q11.2DS) have yielded inconsistent results. The goal of the present study was to replicate a recent finding that executive function is higher in individuals hemizygous for the Met allele.

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