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A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear.

Central Serotonin Transporter Availability Measured With [123I]β-CIT SPECT in Relation to Serotonin Transporter Genotype

Central Serotonin Transporter Availability Measured With [¹²³I]β-CIT SPECT in Relation to Serotonin Transporter Genotype