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A previous positron emission tomography (PET) study reported increased serotonin 5-HT(2A) receptor binding in unmedicated depressed patients with high scores on the Dysfunctional Attitudes Scale. The purpose of the present study was to use the highly selective 5-HT(2A) receptor ligand [(11)C]MDL 100,907 in a PET imaging paradigm to assess 1) 5-HT(2A) receptor binding potential in euthymic subjects with a history of recurrent depression and 2) the relationship between receptor binding and scores on the Dysfunctional Attitudes Scale.

the american journal of psychiatry

Increased 5-HT<sub>2A</sub>Receptor Binding in Euthymic, Medication-Free Patients Recovered From Depression: A Positron Emission Study With [<sup>11</sup>C]MDL 100,907

Increased 5-HT2AReceptor Binding in Euthymic, Medication-Free Patients Recovered From Depression: A Positron Emission Study With [11C]MDL 100,907

Increased 5-HT_2AReceptor Binding in Euthymic, Medication-Free Patients Recovered From Depression: A Positron Emission Study With [¹¹C]MDL 100,907