English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Skeletal muscle injury activates adult myogenic stem cells, known as satellitecells, to initiate proliferation and differentiation to regenerate new muscle fibers.The skeletal muscle-specific microRNA miR-206 is upregulated in satellitecells following muscle injury, but its role in muscle regeneration has not been defined.Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury.Genetic deletion of miR-206 in mice substantially delayed regeneration induced bycardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated thedystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found thatmiR-206 acts to promote satellite cell differentiation and fusion into muscle fibersthrough suppressing a collection of negative regulators of myogenesis. Our findingsreveal an essential role for miR-206 in satellite cell differentiation during skeletalmuscle regeneration and indicate that miR-206 slows progression of Duchenne musculardystrophy.

microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice