English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The field of tumor immunology has enjoyed an explosion of knowledge about the molecular and cellular bases of immune regulation. The identification of antigens expressed by different types of tumors has been critically important, and the field of therapeutic cancer vaccine development is advancing rapidly. Currently, major efforts are focused on developing specific cancer immunotherapy strategies that rely on adoptive transfer of immune cells or the use of tumor-specific antigens (peptides) as vaccines. Such vaccines are expected to augment established anti-tumour immune responses and to induce de novo immunity or reverse tolerance. Major advances have resulted in several immunization strategies designed to boost immune responses to some tumor-associated antigens (1). Strategies involving various forms of peptides, either alone or in combination with different cytokines, adjuvant, or DCs, have been used to enhance specific immune responses. Although the identification of tumor antigens is a crucial step in the design of vaccination strategies, an effective anti-tumor vaccination should also aim to bring tumor antigens to the secondary lymphoid organ in appropriate amounts and within a specific time frame. Obviously, the difficulty consists in achieving such a fine balance in the dynamics and kinetics of antigen administration. Despite the enthusiasm for current vaccination strategies, it should be noted that tumor rejection in patients does not always follow successful induction of tumor-specific immune responses by cancer vaccines. Even if a strong and sustained cytotoxic response is induced, complex issues such as tumor evasion and selection of tumor-resistant variants remain.

Integrating the quality of the cytotoxic response and tumor susceptibility into the design of protective vaccines in tumor immunotherapy