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The Lasker~DeBakey Award for Clinical Medical Research commends individuals whose achievements have profoundly advanced medicine. In 2018, the Albert and Mary Lasker Foundation honors John (Iain) Baird Glen, BVMS, PhD, for his contributions to the practice of anesthesia. Glen (Figure 1) spearheaded the discovery and clinical development of the i.v. anesthetic propofol, which has been identified among anesthesiologists as the most transformative drug in their field (1), as well as the development of a breakthrough infusion system that helped standardize anesthetic delivery. Together, propofol and its infusion system have remodeled expectations for the precision, safety, and tolerability of anesthesia. The pursuit for total i.v. anesthesia William Morton and others performed the first documented surgeries on anesthetized patients in the 1840s, and use of general anesthesia increased steadily throughout the remainder of the century. Early methods relied almost exclusively on gaseous inhalational anesthetics such as ether, chloroform, and nitrous oxide, which typically produced slow-onset anesthesia, sluggish recovery of consciousness, and — often — adverse postoperative effects (2). Anesthetics (i.v.) possessed an important advantage over inhalational methods: they could provide a quicker onset of anesthesia. John Lundy, of the Mayo Clinic, is credited with bringing the i.v. anesthetic sodium thiopental into clinical practice in the 1930s. Injection (i.v.) of thiopental, a highly potent barbiturate, was found to induce anesthesia rapidly and displayed [...] News

The 2018 Lasker~DeBakey Clinical Medical Research Award recognizes John Baird Glen for the discovery of propofol