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The Albert and Mary Lasker Foundation has selected Joan Steitz as the winner of the 2018 Lasker~Koshland Special Achievement Award in Medical Science for her leading role in the field of RNA processing and for promoting the advancement of women in science. A giant in RNA biology Joan Steitz (Figure 1) has made numerous seminal contributions to our understanding of RNA biology. As a postdoctoral researcher, Steitz was the first to describe the translation initiation sites of prokaryotic RNA in 1969 (1). This discovery helped her secure her own lab at Yale University, where she continues an active research program to this day. As an independent investigator, she turned her attention to eukaryotic cells, focusing on why eukaryotic cells produce an excess of RNA in the nucleus that is not found in cytoplasm in the form of mRNA. In 1977, the Sharp and Roberts labs established that eukaryotic mRNA was spliced into a mature form that is exported to the cytoplasm for translation (2). This exciting discovery prompted Steitz to explore the fundamental mechanisms of the splicing process. During the previous year, she had set out to make antibodies against heterogeneous nuclear ribonucleoproteins (hnRNPs), which bind to newly transcribed RNA, but her efforts were unsuccessful due to strong conservation of hnRNPs between species. Taking a different approach in 1978, Steitz [...] News

RNA biologist Joan Steitz awarded the 2018 Lasker~Koshland Special Achievement prize