English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Non-insulin-dependent diabetes mellitus (NIDDM)' is phenotypically heterogenous and may therefore not be explained by one simple pathophysiological mechanism. Despite the heterogenous nature of the disease, the major form as discussed in this review is linked to overweight, arterial hypertension, dyslipidemia, and macroangiopathy (coronary heart disease), all conditions which become more common with aging (1). This form of NIDDMseems to be growing worldwide in the footsteps of Westernized life style. Around 3%in the Western world suffers from the disease, but in subjects 60 yr and older, the prevalence is as high as 10-20% (2). In certain ethnic populations as the Pima Indians and the Nauruans the prevalence approaches 40% (2). Therefore, NIDDM imposes an enormous burden on the health care system all over the world. In general, the goals of treatment are achieved in only a small subset of patients, but nevertheless progression of macroangiopathy is a more severe problem than worsening of glycemia. The overall mortality rate in patients with NIDDMis two to three times higher than in control subjects, primarily due to excess mortality of coronary heart disease (2). Of note, 40% of patients already suffer from clinical macroangiopathy at diagnosis, indicating that these complications may not be secondary to the diabetic state itself, but rather a part of the NIDDM syndrome, also referred to as Syndrome X or "The Insulin Resistance Syndrome" (1). Resistance to the action of insulin on glucose metabolism in skeletal muscle has been proposed as the inherited basis for this syndrome and since insulin resistance is observed several decades before the onset of hyperglycemia an early detection can open the prospect of intervention in order to prevent the disease process (4-7). The present review discusses the metabolic and genetic background of NIDDMtogether with the current knowledge of the sequence of events leading to NIDDM. Based on that a new

Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus.