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Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F(1alpha) &lt; A(2), F(2alpha), B(2) &lt; A(1) &lt; E(2) &lt; E(1). Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.

Prostaglandins and Their Effects on Human Placental Adenyl Cyclase